SAMSN1
Function
Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity).
Tissue Specificity
Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood.
Cellular localization
- Nucleus
- Cytoplasm
- Cell projection
- Ruffle
- Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles (By similarity).
Alternative names
HACS1, SAMSN1, SAM domain-containing protein SAMSN-1, Hematopoietic adaptor containing SH3 and SAM domains 1, Nash1, SH3-SAM adaptor protein