SAP130
Domain
The N-terminus may interact with a transcriptional coactivator.
The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors.
Function
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
Post-translational modifications
Acetylated.
Sumoylated with SUMO1.
Sequence Similarities
Belongs to the SAP130 family.
Tissue Specificity
Expressed in various cancer cell ines.
Cellular localization
- Nucleus
Alternative names
Histone deacetylase complex subunit SAP130, 130 kDa Sin3-associated polypeptide, Sin3-associated polypeptide p130, SAP130