SAYSD1
Domain
The middle helical (MH) region recognizes and binds ufmylated ribosomes.
Function
Ufmylation 'reader' component of a translocation-associated quality control pathway, a mechanism that takes place when a ribosome has stalled during translation, and which is required to degrade clogged substrates (PubMed:36848233). Specifically recognizes and binds ufmylated ribosomes when a ribosome has stalled, promoting the transport of stalled nascent chain via the TRAPP complex to lysosomes for degradation (PubMed:36848233).
Sequence Similarities
Belongs to the SAYSD1 family.
Cellular localization
- Endoplasmic reticulum membrane
- Cytoplasmic vesicle membrane
Alternative names
C6orf64, SAYSD1, SAYSvFN domain-containing protein 1