SCARA5
Function
Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Preferentially binds ferritin light chain (FTL) compared to heavy chain (FTH1).
Sequence Similarities
Belongs to the SCARA5 family.
Cellular localization
- Cell membrane
- Single-pass type II membrane protein
Alternative names
UNQ2938/PRO28700, SCARA5, Scavenger receptor class A member 5, Scavenger receptor hlg