Scarb1

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218).

(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718).

(Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus.

(Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding.

N-glycosylated.

The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.

Belongs to the CD36 family.

Widely expressed.

• Cell membrane
• Multi-pass membrane protein
• Membrane
• Caveola
• Multi-pass membrane protein
• Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.

CD36, CD36L1, CLA1, SCARB1, Scavenger receptor class B member 1, SRB1, CD36 and LIMPII analogous 1, CD36 antigen-like 1, SR-BI, CLA-1

• entrezGene:949
• omim:601040
• swissprot:Q8WTV0

Proteins

Metabolism

60878Da