SCD
GeneName
SCD
Summary
SCD, also known as SCD-1 or SCD1, is a 42 kDa enzyme predominantly localised to the endoplasmic reticulum and its membrane. It functions as a desaturase, catalysing the conversion of saturated fatty acids into monounsaturated fatty acids, specifically through its palmitoyl-CoA and stearoyl-CoA 9-desaturase activities. This enzyme is involved in the biosynthesis of unsaturated fatty acids, playing a crucial role in lipid metabolism and energy homeostasis, and is responsive to changes in fatty acid levels and temperature regulation.
Importance
SCD is relevant to: - Metabolic disorders, including obesity and insulin resistance, due to its role in fatty acid composition and energy balance - Cold-induced thermogenesis, as it positively regulates the process of heat production in response to cold exposure - Cardiovascular health, given its influence on lipid profiles and potential impact on atherosclerosis - Cancer biology, where altered fatty acid metabolism can affect tumour growth and progression
Top Products
For researchers investigating SCD, we recommend two excellent primary antibodies. The first is the well-cited Anti-SCD1 antibody [CD.E10] (ab19862), which has garnered 105 citations, reflecting its strong reputation in the field. This antibody is validated for use in various applications, including Western blotting (WB), immunohistochemistry (IHC), immunocytochemistry (ICC), flow cytometry (FC), and immunoprecipitation (IP). Importantly, it has also been validated in knockout models, ensuring reliable performance in your experiments.Additionally, we offer the recombinant antibody, Anti-SCD1 antibody [EPR21963] (ab236868). This product is also validated in knockout models and is suitable for the same range of applications as the top-cited antibody. With 49 citations, it is gaining traction among researchers. The recombinant nature of this antibody provides batch-to-batch consistency, making it a dependable choice for your SCD studies.
Abcam Product Citation Summary
The data indicates that SCD antibodies from Abcam have been effectively used in various studies involving human and mouse models, particularly in liver tissues and kidney sections. The applications primarily include Western blotting and immunohistochemistry, highlighting the relevance of SCD in metabolic processes and disease contexts such as hepatic adaptive UPR and polycystic kidney disease.
Abcam Product Citation Table
Domain
The histidine box domains are involved in binding the catalytic metal ions.
Function
Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).
Sequence Similarities
Belongs to the fatty acid desaturase type 1 family.
Tissue Specificity
Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung.
Cellular localization
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
Alternative names
FADS5, SCD1, SCDOS, SCD, Stearoyl-CoA desaturase, hSCD1, Acyl-CoA desaturase, Delta(9)-desaturase, Fatty acid desaturase, Delta-9 desaturase