Scg3
Function
Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:16219686). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (PubMed:12388744). May also play a role in angiogenesis (PubMed:28330905). Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (By similarity).
Tissue Specificity
Expressed in various brain areas, with highest levels in the arcuate nucleus and the lateral hypothalamic area, as well as the paraventricular nucleus and the ventromedial hypothalamus (at protein level).
Cellular localization
- Cytoplasmic vesicle
- Secretory vesicle
- Cytoplasmic vesicle
- Secretory vesicle membrane
- Peripheral membrane protein
- Secreted
- Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts.
Alternative names
Secretogranin-3, Secretogranin III, SgIII, Scg3