SCG3
Function
Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:19357184). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed:29154827).
Post-translational modifications
O-glycosylated.
Tissue Specificity
Detected in urine (at protein level) (PubMed:25326458). Expressed in brain, heart, kidney, liver and skeletal muscle.
Cellular localization
- Cytoplasmic vesicle
- Secretory vesicle
- Cytoplasmic vesicle
- Secretory vesicle membrane
- Peripheral membrane protein
- Secreted
- Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts.
Alternative names
UNQ2502/PRO5990, SCG3, Secretogranin-3, Secretogranin III, SgIII