SCG5
Function
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
Post-translational modifications
Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides.
Sulfated on tyrosine residues.
Sequence Similarities
Belongs to the 7B2 family.
Cellular localization
- Secreted
- Neuroendocrine and endocrine secretory granules.
Alternative names
SGNE1, SCG5, Neuroendocrine protein 7B2, Pituitary polypeptide, Secretogranin V, Secretogranin-5, Secretory granule endocrine protein I