SCN10A

Expressed in dorsal root ganglia at 15 dpc onwards.

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.

Ubiquitinated by NEDD4L; which promotes its endocytosis.

Phosphorylation at Ser-1452 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.

Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 815) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4.

Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.

Expressed in dorsal root ganglia, trigeminal ganglia, nodose ganglia and sciatic nerve.

• Cell membrane
• Multi-pass membrane protein
• It can be translocated to the cell membrane through association with S100A10.

Sns, Scn10a, Sodium channel protein type 10 subunit alpha, Peripheral nerve sodium channel 3, Sensory neuron sodium channel, Sodium channel protein type X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8, PN3

• entrezGene:29571
• swissprot:Q62968

Proteins

Neuroscience

219733Da