Scnn1b
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Post-translational modifications
N-glycosylated. N-glycosylation is required for interaction with BPIFA1.
Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation.
Sequence Similarities
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily.
Tissue Specificity
Lung and kidney.
Cellular localization
- Apical cell membrane
- Multi-pass membrane protein
- Cytoplasmic vesicle membrane
- Apical membrane of epithelial cells.
Alternative names
Amiloride-sensitive sodium channel subunit beta, Beta-NaCH, Epithelial Na(+) channel subunit beta, Nonvoltage-gated sodium channel 1 subunit beta, SCNEB, Beta-ENaC, Scnn1b