SCUBE2
Domain
The CUB domain is important for the interaction with the cholesterol-anchor of SHH. The CUB domain regulates protease recruitment and activation during SHH shedding.
Function
Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22677548, PubMed:22902404). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).
Post-translational modifications
N-glycosylated.
Tissue Specificity
Expressed in a broad spectrum of adult tissues (PubMed:12270931).
Cellular localization
- Secreted
- Cell surface
- Secreted and tethered at the cell surface (PubMed:19480626).
Alternative names
CEGP1, SCUBE2, Protein CEGP1, Scube/You