Syndecan-1

The protein expressed by the SDC1 gene is a cell surface proteoglycan with heparan sulfate and chondroitin sulfate, linking the cytoskeleton to the interstitial matrix. It regulates exosome biogenesis alongside SDCBP and PDCD6IP. This supplementary information is collated from multiple sources and compiled automatically.

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.

Belongs to the syndecan proteoglycan family.

Detected in placenta (at protein level) (PubMed:32337544). Detected in fibroblasts (at protein level) (PubMed:36213313).

• Membrane
• Single-pass type I membrane protein
• Secreted
• Secreted
• Extracellular exosome
• Shedding of the ectodomain produces a soluble form.

CD138, SDC, SDC1, Syndecan-1, SYND1

• entrezGene:6382
• omim:186355
• swissprot:P18827

Proteins

Oncology

32462Da