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Syndecan-1
Function
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).
Post-translational modifications
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
Sequence similarities
Belongs to the syndecan proteoglycan family.
Cellular localization
- Membrane
- Single-pass type I membrane protein
- Secreted
- Secreted
- Extracellular exosome
- Shedding of the ectodomain produces a soluble form.
Alternative names
- Syndecan-1
- SYND1
- SDC
- SDC1
Database links
Target type
Proteins
Primary research area
Oncology
Molecular weight
32462Da