SDC1
GeneName
SDC1
Summary
SDC1, also known as syndecan-1 or SDC, is a 32 kDa transmembrane proteoglycan predominantly expressed on the surface of various cell types, including epithelial and endothelial cells. It plays a significant role in cell adhesion, migration, and communication by serving as a receptor for extracellular matrix components and growth factors. SDC1 is localised to the plasma membrane and is involved in processes such as receptor-mediated endocytosis and the regulation of exosomal secretion. Additionally, it participates in the canonical Wnt signalling pathway and myoblast development, highlighting its importance in tissue development and homeostasis.
Importance
SDC1 is relevant to: - Cancer biology, as it influences tumour cell behaviour, including migration and invasion, through its interactions with the extracellular matrix. - Tissue repair and regeneration, given its role in cell migration and development of striated muscle cells. - Cardiovascular research, due to its involvement in endothelial function and vascular integrity. - Neurobiology, as it may play a role in exosomal communication and signalling in the nervous system.
Top Products
For researchers investigating SDC1, we recommend two primary antibodies that stand out for their performance. The first is the well-cited monoclonal antibody, Anti-Syndecan-1 antibody [B-A38] (ab34164), which has garnered 54 citations, highlighting its reliability in flow cytometry (FC). Additionally, we offer the recombinant antibody, Anti-Syndecan-1 antibody [SP152] (ab130405), which is validated for use in flow cytometry (FC), immunohistochemistry (IHC), and immunocytochemistry (ICC). With 6 citations, this recombinant product provides the added benefit of batch-to-batch consistency, making it an excellent choice for researchers seeking dependable results in their studies of SDC1. The Anti-Syndecan-1 antibody [SP152] ELISA Kit (ab130405), supported by 6 citations, is an excellent option for researchers looking to accurately measure SDC1 in their experiments.
Abcam Product Citation Summary
The data indicates that SDC1 is being investigated in various human and rat studies, particularly in the context of tumour tissues, septic shock, and cardiopulmonary bypass. The use of immunohistochemistry and immunofluorescence suggests a focus on the localisation and expression levels of SDC1 in these biological contexts.
Abcam Product Citation Table
Function
Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity).
Post-translational modifications
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
Sequence Similarities
Belongs to the syndecan proteoglycan family.
Tissue Specificity
Detected in placenta (at protein level) (PubMed:32337544). Detected in fibroblasts (at protein level) (PubMed:36213313).
Cellular localization
- Membrane
- Single-pass type I membrane protein
- Secreted
- Secreted
- Extracellular exosome
- Shedding of the ectodomain produces a soluble form.
Alternative names
CD138, SDC, SDC1, Syndecan-1, SYND1