Syndecan 4

Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP.

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.

O-glycosylated; contains both chondroitin sulfate and heparan sulfate. Ser-44, Ser-62 and Ser-64 can all be modified by either chondroitin sulfate or heparan sulfate, and the protein exists in forms that contain only chondroitin sulfate, only heparan sulfate and both chondroitin sulfate and heparan sulfate.

Belongs to the syndecan proteoglycan family.

Ubiquitous. Highest levels in liver, kidney and lung.

• Membrane
• Single-pass type I membrane protein
• Secreted
• Shedding of the ectodomain produces a soluble form.

Syndecan-4, SYND4, Ryudocan core protein, Sdc4

• entrezGene:20971
• swissprot:O35988

Proteins

Oncology

21482Da