SDCBP2

Domain

Binds phosphatidylinositol 4,5-bisphosphate (PIP2) via its two PDZ domains. These domains target SDCBP2 to the plasma membranes and nucleoli, two PIP2-rich regions.

Function

Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997).

Tissue Specificity

Preferentially expressed in cells of the digestive tract (PubMed:11102519). Low expression in skeletal muscle and kidney (PubMed:11102519). Detected in differentiated keratinocytes of normal and malignant epithelium (PubMed:22623796). In healthy skin, expression is localized in suprabasal epidermal layers (PubMed:22623796).

Cellular localization

• Cytoplasm
• Nucleus
• Nucleolus
• Nucleus
• Nucleoplasm
• Cell membrane
• Nucleus speckle
• Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments (PubMed:11102519). Colocalizes with TM4SF1 in the apical region of the cell (PubMed:11102519). Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments (PubMed:15961997). PIP2 plays an important role in the distribution of SDCBP2 (PubMed:23300061).

Alternative names

SITAC18, SDCBP2, Syntenin-2, Similar to TACIP18, Syndecan-binding protein 2, SITAC

Database links

swissprot:Q9H190 genbank:NP_536737 omim:602217 genbank:NP_056500 entrezGene:27111