SDHB

Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:2902878). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (PubMed:1864383, PubMed:2902878). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (PubMed:2902878).

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

• Mitochondrion inner membrane
• Peripheral membrane protein
• Matrix side

Iron-sulfur subunit of complex II, Malate dehydrogenase [quinone] iron-sulfur subunit, IP, SDHB

• entrezGene:286840
• swissprot:Q3T189

Proteins

Cardiovascular

31518Da