SDS
Function
Catalyzes the pyridoxal-phosphate-dependent dehydrative deamination of L-threonine and L-serine to ammonia and alpha-ketobutyrate and pyruvate, respectively.
Pathway
Carbohydrate biosynthesis; gluconeogenesis.
Sequence Similarities
Belongs to the serine/threonine dehydratase family.
Tissue Specificity
Predominantly expressed in the perivenous regions of the liver.
Cellular localization
- Cytoplasm
Alternative names
SDH, SDS, L-serine dehydratase/L-threonine deaminase, Hepatic serine dehydratase, L-serine deaminase, L-threonine dehydratase, hSDH, TDH