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SDSL

Function

Catalyzes the pyridoxal-phosphate-dependent dehydrative deamination of L-threonine and L-serine to ammonia and alpha-ketobutyrate and pyruvate, respectively (PubMed:16580895, PubMed:18342636). Also exhibits racemase activity towards L-glutamate and D-glutamate (By similarity).

Sequence Similarities

Belongs to the serine/threonine dehydratase family.

Tissue Specificity

Expressed in lung cancer cell lines.

Alternative names

Serine dehydratase-like, Cancerous serine dehydratase, Glutamate racemase, L-serine deaminase, L-serine dehydratase/L-threonine deaminase, L-threonine dehydratase, Serine dehydratase 2, cSDH, SDHL, TDH, SDH 2, SDSL

swissprot:Q96GA7 entrezGene:113675