SEC14L2
Developmental stage
Low expression in fetal tissues.
Function
Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
Tissue Specificity
Widely expressed. Strong expression in liver, brain and prostate.
Cellular localization
- Cytoplasm
- Nucleus
- Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol.
Alternative names
C22orf6, KIAA1186, KIAA1658, SEC14L2, SEC14-like protein 2, Alpha-tocopherol-associated protein, Squalene transfer protein, Supernatant protein factor, TAP, hTAP, SPF