SEC14L2

Low expression in fetal tissues.

Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.

Widely expressed. Strong expression in liver, brain and prostate.

• Cytoplasm
• Nucleus
• Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol.

C22orf6, KIAA1186, KIAA1658, SEC14L2, SEC14-like protein 2, Alpha-tocopherol-associated protein, Squalene transfer protein, Supernatant protein factor, TAP, hTAP, SPF

• entrezGene:23541
• omim:607558
• swissprot:O76054

Proteins

46145Da