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SEC22B

Function

SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.

Sequence similarities

Belongs to the synaptobrevin family.

Cellular localization

  • Endoplasmic reticulum membrane
  • Single-pass type IV membrane protein
  • Endoplasmic reticulum-Golgi intermediate compartment membrane
  • Golgi apparatus
  • Cis-Golgi network membrane
  • Golgi apparatus
  • Trans-Golgi network membrane
  • Melanosome
  • Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).

Alternative names

  • Vesicle-trafficking protein SEC22b
  • ER-Golgi SNARE of 24 kDa
  • SEC22 vesicle-trafficking protein homolog B
  • SEC22 vesicle-trafficking protein-like 1
  • ERS-24
  • ERS24
  • SEC22L1
  • SEC22B

Target type

Proteins

Molecular weight

24593Da