Vesicle-trafficking protein SEC22b

SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.

Belongs to the synaptobrevin family.

• Endoplasmic reticulum membrane
• Single-pass type IV membrane protein
• Endoplasmic reticulum-Golgi intermediate compartment membrane
• Golgi apparatus
• cis-Golgi network membrane
• Golgi apparatus
• trans-Golgi network membrane
• Melanosome
• Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).

SEC22L1, SEC22B, Vesicle-trafficking protein SEC22b, ER-Golgi SNARE of 24 kDa, SEC22 vesicle-trafficking protein homolog B, SEC22 vesicle-trafficking protein-like 1, ERS-24, ERS24

• entrezGene:9554
• omim:604029
• swissprot:O75396

Proteins

Neuroscience

24593Da