SEC31B
Function
As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum.
Post-translational modifications
Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.
Sequence Similarities
Belongs to the WD repeat SEC31 family.
Tissue Specificity
Ubiquitously expressed at low levels with specific expression in thymus and testis. Expressed in testis by Sertoli cells, Leydig cells and spermatogonia and in cerebellum more prominently by Purkinje and granular cells (at protein level).
Cellular localization
- Cytoplasm
- Cytoplasmic vesicle
- COPII-coated vesicle membrane
- Peripheral membrane protein
- Cytoplasmic side
- Endoplasmic reticulum membrane
- Peripheral membrane protein
Alternative names
SEC31L2, SEC31B, Protein transport protein Sec31B, SEC31-like protein 2, SEC31-related protein B, SEC31B-1