SEL1L

Function

Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509, PubMed:29997207). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.

Post-translational modifications

N-glycosylated.

Sequence Similarities

Belongs to the sel-1 family.

Tissue Specificity

Highly expressed in pancreas.

Cellular localization

• Endoplasmic reticulum membrane
• Single-pass type I membrane protein

Alternative names

TSA305, UNQ128/PRO1063, SEL1L, Protein sel-1 homolog 1, Suppressor of lin-12-like protein 1, Sel-1L

Database links

swissprot:Q9UBV2 entrezGene:6400 swissprot:Q12916 omim:602329