SELENOF
Function
May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic reticulum (PubMed:24415556). May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (PubMed:24415556).
Post-translational modifications
The N-terminus is blocked.
Sequence Similarities
Belongs to the selenoprotein M/F family.
Tissue Specificity
Higher levels in prostate and thyroid gland.
Cellular localization
- Endoplasmic reticulum lumen
- The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum.
Alternative names
SEP15, SELENOF, Selenoprotein F, 15 kDa selenoprotein