SELENOP
Domain
The C-terminus is not required for endocytic uptake in the proximal tubule epithelium.
Function
Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.
Post-translational modifications
Phosphorylation sites are present in the extracellular medium.
Sequence Similarities
Belongs to the selenoprotein P family.
Tissue Specificity
Made in the liver and heart and secreted into the plasma. It is also found in the kidney.
Cellular localization
- Secreted
- Passes from plasma into the glomerular filtrate where it is removed by endocytosis mediated by LRP2 in the proximal tubule epithelium.
Alternative names
SELP, SEPP1, SELENOP, Selenoprotein P, SeP