SELENOT
Function
Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress and cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity).
Involvement in disease
mRNA levels are increased more than 200-folds in the caudate putamen from Parkinson disease (PD) patients compared to control subjects. In conditional brain knockout mice, treatment with PD-inducing neurotoxins provoke rapid and severe parkinsonian-like motor defects.
Post-translational modifications
May contain a selenide-sulfide bond between Cys-46 and Sec-49. This bond is speculated to serve as redox-active pair (By similarity).
Sequence Similarities
Belongs to the SelWTH family. Selenoprotein T subfamily.
Tissue Specificity
Ubiquitous. Highly expressed in the endocrine pancreas.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass membrane protein
Alternative names
SELT, UNQ150/PRO176, SELENOT, Thioredoxin reductase-like selenoprotein T, SelT