Sell

Function

Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes (PubMed:1693096). Promotes initial tethering and rolling of leukocytes in endothelia (By similarity).

Post-translational modifications

N-glycosylated.

Sequence Similarities

Belongs to the selectin/LECAM family.

Tissue Specificity

Predominantly expressed in lymphoid tissue.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

CD62L, Lnhr, Ly-22, Ly22, Sell, L-selectin, CD62 antigen-like family member L, Leukocyte adhesion molecule 1, Leukocyte-endothelial cell adhesion molecule 1, Lymph node homing receptor, Lymphocyte antigen 22, Lymphocyte surface MEL-14 antigen, LAM-1, LECAM1

Database links

swissprot:P18337 entrezGene:20343

Other research areas

• Immuno-oncology