SELL

Function

Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28011641, PubMed:28489325). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).

Post-translational modifications

N-glycosylated.

Sequence Similarities

Belongs to the selectin/LECAM family.

Tissue Specificity

Expressed in B-cell lines and T-lymphocytes.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

CD62L, LNHR, LYAM1, SELL, L-selectin, CD62 antigen-like family member L, Leukocyte adhesion molecule 1, Leukocyte surface antigen Leu-8, Leukocyte-endothelial cell adhesion molecule 1, Lymph node homing receptor, TQ1, gp90-MEL, LAM-1, LECAM1

Database links

swissprot:P14151 omim:153240 entrezGene:6402

Other research areas

• Immuno-oncology