SELP

Function

Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.

Involvement in disease

Ischemic stroke

ISCHSTR

A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.

None

Disease susceptibility is associated with variants affecting the gene represented in this entry.

Sequence similarities

Belongs to the selectin/LECAM family.

Tissue specificity

Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

• P-selectin
• CD62 antigen-like family member P
• Granule membrane protein 140
• Leukocyte-endothelial cell adhesion molecule 3
• Platelet activation dependent granule-external membrane protein
• GMP-140
• LECAM3
• PADGEM
• GMRP
• GRMP
• SELP

Database links

• entrezGene:6403
• omim:173610
• swissprot:P16109
• swissprot:P49908
• swissprot:Q5TI43
• swissprot:Q6NUL9
• swissprot:Q5TI47
• swissprot:Q5TI46
• swissprot:Q5TI45

Target type

Proteins

Primary research area

Cardiovascular

Molecular weight

90834Da