Expressed early in embryonic development (11 dpc) in distinct regions of the neuroectoderm and mesoderm. Expression became more extensive at later stages.
Strong binding to neuropilin is mediated by the carboxy third of the protein.
Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity).
Belongs to the semaphorin family.
Semad, SemD, Sema3a, Semaphorin-3A, Semaphorin III, Semaphorin-D, Sema III, Sema D
Proteins
Developmental Biology
88813Da
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