Sema3a
Developmental stage
Expressed early in embryonic development (11 dpc) in distinct regions of the neuroectoderm and mesoderm. Expression became more extensive at later stages.
Domain
Strong binding to neuropilin is mediated by the carboxy third of the protein.
Function
Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity).
Sequence Similarities
Belongs to the semaphorin family.
Cellular localization
- Secreted
Alternative names
Semad, SemD, Sema3a, Semaphorin-3A, Semaphorin III, Semaphorin-D, Sema III, Sema D