SEMA4C
Function
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.
Sequence Similarities
Belongs to the semaphorin family.
Cellular localization
- Postsynaptic density membrane
- Single-pass type I membrane protein
- Cytoplasmic vesicle
- Secretory vesicle
- Synaptic vesicle membrane
- Single-pass type I membrane protein
Alternative names
KIAA1739, SEMAI, UNQ5855/PRO34487, SEMA4C, Semaphorin-4C