SEMA6A
Function
Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.
(Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium.
Sequence Similarities
Belongs to the semaphorin family.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
KIAA1368, SEMAQ, SEMA6A, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1, Sema VIA, SEMA6A-1