Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Belongs to the semaphorin family.
Highly expressed in activated T-cells (at protein level). Highest expression in brain. Lower in heart, thymus, spleen, testis and ovary. The expression increases in late embryonic and postnatal stages. Detected in T-cells.
CD108, Cd108, Semal, Semk1, Sema7a, Semaphorin-7A, Semaphorin-K1, Semaphorin-L, Sema K1, Sema L
Proteins
Immuno-oncology
74994Da
We found 3 products in 1 category
ab23578