Sema7a
Function
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Sequence Similarities
Belongs to the semaphorin family.
Tissue Specificity
Highly expressed in activated T-cells (at protein level). Highest expression in brain. Lower in heart, thymus, spleen, testis and ovary. The expression increases in late embryonic and postnatal stages. Detected in T-cells.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Extracellular side
Alternative names
CD108, Cd108, Semal, Semk1, Sema7a, Semaphorin-7A, Semaphorin-K1, Semaphorin-L, Sema K1, Sema L