SENP2

Domain

The N-terminus is necessary and sufficient for nuclear envelope targeting.

Function

Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).

Post-translational modifications

Polyubiquitinated; which leads to proteasomal degradation.

Sequence similarities

Belongs to the peptidase C48 family.

Cellular localization

• Nucleus
• Nuclear pore complex
• Nucleus membrane
• Peripheral membrane protein
• Nucleoplasmic side
• Cytoplasm
• Shuttles between cytoplasm and nucleus.

Alternative names

• Sentrin-specific protease 2
• Axam2
• SMT3-specific isopeptidase 2
• Sentrin/SUMO-specific protease SENP2
• Smt3ip2
• SENP2
• KIAA1331

Database links

• entrezGene:59343
• omim:608261
• swissprot:Q9HC62

Target type

Proteins

Primary research area

Epigenetics

Molecular weight

67855Da