SENP5
Function
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.
Sequence Similarities
Belongs to the peptidase C48 family.
Cellular localization
- Nucleus
- Nucleolus
Alternative names
FKSG45, SENP5, Sentrin-specific protease 5, Sentrin/SUMO-specific protease SENP5