SENP8

Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.

Belongs to the peptidase C48 family.

Broadly expressed, with highest levels in kidney and pancreas.

DEN1, NEDP1, PRSC2, FKSG8, SENP8, Sentrin-specific protease 8, Deneddylase-1, NEDD8-specific protease 1, Sentrin/SUMO-specific protease SENP8

• entrezGene:123228
• omim:608659
• swissprot:Q96LD8

Proteins

Oncology

24107Da