SENP8
Function
Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
Sequence Similarities
Belongs to the peptidase C48 family.
Tissue Specificity
Broadly expressed, with highest levels in kidney and pancreas.
Alternative names
DEN1, NEDP1, PRSC2, FKSG8, SENP8, Sentrin-specific protease 8, Deneddylase-1, NEDD8-specific protease 1, Sentrin/SUMO-specific protease SENP8