SEPTIN14
Developmental stage
Expressed in all cell stages of spermatogenesis.
Function
Filament-forming cytoskeletal GTPase (Probable). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Plays a role in sperm head formation during spermiogenesis, potentially via facilitating localization of ACTN4 to cell filaments (PubMed:33228246).
Sequence Similarities
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Tissue Specificity
Testis-specific (at protein level).
Cellular localization
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Cell projection
- Axon
- Cell projection
- Dendrite
- Perikaryon
- Cytoplasm
- Perinuclear region
- Cytoplasmic vesicle
- Secretory vesicle
- Acrosome
- Colocalizes with actin stress fibers (PubMed:17922164). Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (By similarity).
Alternative names
SEPT14, SEPTIN14, Septin-14