SEPTIN5
Function
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity).
Post-translational modifications
Phosphorylated by DYRK1A (By similarity). In platelets, phosphorylated in response to thrombin, phorbol-12-myristate-13-acetate and collagen.
Sequence Similarities
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Tissue Specificity
Expressed at high levels in the CNS, as well as in heart and platelets (at protein level).
Cellular localization
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- In platelets, found in areas surrounding alpha-granules.
Alternative names
PNUTL1, SEPT5, SEPTIN5, Septin-5, Cell division control-related protein 1, Peanut-like protein 1, CDCrel-1