SERBP1
Function
Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742).
Post-translational modifications
Phosphorylation by MTOR inhibits SERBP1 and relieves ribosome hibernation.
Sequence Similarities
Belongs to the SERBP1-HABP4 family.
Tissue Specificity
Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain.
Cellular localization
- Cytoplasm
- Nucleus
- Cytoplasm
- Perinuclear region
Alternative names
PAIRBP1, CGI-55, SERBP1, SERPINE1 mRNA-binding protein 1, PAI1 RNA-binding protein 1, Plasminogen activator inhibitor 1 RNA-binding protein, PAI-RBP1