Serine racemase
Function
Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
Post-translational modifications
S-nitrosylated, leading to decrease the enzyme activity.
Sequence Similarities
Belongs to the serine/threonine dehydratase family.
Tissue Specificity
Expressed in the hippocampus (at protein level) (Ref.6). Expressed in the small intestine (PubMed:35915065).
Alternative names
Serine racemase, D-serine ammonia-lyase, D-serine dehydratase, L-serine ammonia-lyase, L-serine dehydratase, Srr