Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.

Ubiquitinated by E3 CUL3-KLHL15 complex; this modification leads to proteasomal degradation.

Belongs to the phosphatase 2A regulatory subunit B56 family.

Highest expression in brain.

• Cytoplasm

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform, PP2A B subunit isoform B'-beta, PP2A B subunit isoform B56-beta, PP2A B subunit isoform PR61-beta, PP2A B subunit isoform R5-beta, PPP2R5B

• entrezGene:5526
• ncbi:5453952
• omim:601644
• swissprot:Q15173

Proteins

Oncology

57393Da