Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
Function
As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.
Post-translational modifications
Ubiquitinated by E3 CUL3-KLHL15 complex; this modification leads to proteasomal degradation.
Sequence Similarities
Belongs to the phosphatase 2A regulatory subunit B56 family.
Tissue Specificity
Highest expression in brain.
Cellular localization
- Cytoplasm
Alternative names
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform, PP2A B subunit isoform B'-beta, PP2A B subunit isoform B56-beta, PP2A B subunit isoform PR61-beta, PP2A B subunit isoform R5-beta, PPP2R5B