SERPINA4
Function
Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.
Post-translational modifications
The N-terminus is blocked.
Sequence Similarities
Belongs to the serpin family.
Tissue Specificity
Expressed by the liver and secreted in plasma.
Cellular localization
- Secreted
Alternative names
KST, PI4, SERPINA4, Kallistatin, Kallikrein inhibitor, Peptidase inhibitor 4, Serpin A4, PI-4