Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids.
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Corticosteroid-binding globulin deficiency
CBG deficiency
Extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.
None
The disease is caused by variants affecting the gene represented in this entry.
N-glycosylated; binds 5 oligosaccharide chains.
Glycosylation in position Asn-260 is needed for steroid binding.
Belongs to the serpin family.
Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.
CBG, SERPINA6, Corticosteroid-binding globulin, Serpin A6, Transcortin
Proteins
Metabolism
45141Da
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