SERPINB3
Developmental stage
Its expression is closely related to cellular differentiation in both normal and malignant squamous cells.
Function
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).
Sequence Similarities
Belongs to the serpin family. Ov-serpin subfamily.
Tissue Specificity
Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).
Cellular localization
- Cytoplasm
- Seems to also be secreted in plasma by cancerous cells but at a low level.
Alternative names
SCCA, SCCA1, SERPINB3, Serpin B3, Protein T4-A, Squamous cell carcinoma antigen 1, SCCA-1