SERPINB5
Function
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Sequence Similarities
Belongs to the serpin family. Ov-serpin subfamily.
Tissue Specificity
Normal mammary epithelial cells.
Cellular localization
- Secreted
- Extracellular space
Alternative names
PI5, SERPINB5, Serpin B5, Maspin, Peptidase inhibitor 5, PI-5