Serpinc1
Function
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).
Post-translational modifications
Phosphorylated by FAM20C in the extracellular medium.
Sequence Similarities
Belongs to the serpin family.
Tissue Specificity
Plasma.
Cellular localization
- Secreted
- Extracellular space
Alternative names
At3, Serpinc1, Antithrombin-III, ATIII, Serpin C1