SERPINE1

Function

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).

Sequence similarities

Belongs to the serpin family.

Cellular localization

• Secreted

Alternative names

• Plasminogen activator inhibitor 1
• PAI
• PAI-1
• Endothelial plasminogen activator inhibitor
• Serpin E1
• Serpine1
• Pai1
• Planh1

Database links

• swissprot:P20961

Target type

Proteins