Serpinf1
Developmental stage
First detected at 12.5 dpc in cartilage primordium, it is present in the osseous matrix of developing limbs, vertebrae, ribs and skull. At 16.5 dpc it is detected in bone matrix and smooth muscle, and at lower levels in connective tissue, bronchial epithelial cells, metanephron microtubules, and skin.
Function
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Sequence Similarities
Belongs to the serpin family.
Tissue Specificity
Highly expressed in the liver, gastric glandular mucosa and renal tubules. It is also expressed in the brain, heart, lung retina and testes.
Cellular localization
- Secreted
- Melanosome
Alternative names
Pedf, Sdf3, Serpinf1, Pigment epithelium-derived factor, PEDF, Caspin, Serpin F1, Stromal cell-derived factor 3, SDF-3