SESN3
Domain
The N-terminal domain may have an alkylhydroperoxide reductase activity.
The C-terminal domain mediates interaction with GATOR2 through which it regulates TORC1 signaling.
Function
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity).
Sequence Similarities
Belongs to the sestrin family.
Tissue Specificity
Widely expressed.
Cellular localization
- Cytoplasm
Alternative names
SEST3, SESN3, Sestrin-3