SESTD1
Function
May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1.
Sequence Similarities
Belongs to the SOLO family.
Tissue Specificity
Broad expression. High expression in thalamus and brain. Significantly expressed in vasculature.
Alternative names
SOLO, SESTD1, SEC14 domain and spectrin repeat-containing protein 1, Huntingtin-interacting protein-like protein, Protein Solo