SETD3
Developmental stage
Protein levels peak in S phase and are lowest during M phase (at protein level).
Domain
The SET domain specifically recognizes and binds actin, suggesting that it does not accommodate substrates diverging from actin.
Function
Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018).
Post-translational modifications
Phosphorylated by GSK3B, which is required for recognition by the SCF(FBXW7) complex and subsequent degradation.
Ubiquitinated by the SCF(FBXW7) complex following phosphorylation by GSK3B, leading to its degradation by the proteasome.
Sequence Similarities
Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
Cellular localization
- Cytoplasm
- Nucleus
- Localizes mainly in the cytoplasm.
Alternative names
C14orf154, SETD3, Actin-histidine N-methyltransferase, Protein-L-histidine N-tele-methyltransferase, SET domain-containing protein 3, hSETD3